Hereditary cancer due to pathological mutations in the mismatch repair gene family is now known as Lynch syndrome and affects at least 1 in 1,000 people, resulting in a 30-50% cancer risk most often involving the colorectum and endometrium. Annual or biennial colonoscopy reduces cancer deaths and many offer gynaecological surveillance, but most other associated cancers are not amenable to early detection. As microsatellite instability testing and tumour immunohistochemistry become routine, case finding will improve. Our recent demonstration that 600 mg aspirin per day for at least 2 years reduces the cancer burden by 63% after a 3-year lag period reinforces the need to identify gene carriers and introduce them to chemoprevention. CaPP3 will test different doses of aspirin in at least 3,000 gene carriers to determine whether low-dose aspirin is as effective.

译文

:由于失配修复基因家族中的病理突变而引起的遗传性癌症现在被称为Lynch综合征,它影响至少1,000人中的1个人,导致30-50%的癌症风险最常涉及结直肠癌和子宫内膜癌。一年一次或每两年一次的结肠镜检查可以减少癌症死亡,并且许多可以提供妇科检查,但是大多数其他相关的癌症不适合早期发现。随着微卫星不稳定性测试和肿瘤免疫组织化学成为常规方法,病例发现将得到改善。我们最近的研究表明,在3年的滞后期之后,每天至少2年每天600 mg阿司匹林可以减少63%的癌症负担,从而增强了识别基因载体并将其引入化学预防的需求。 CaPP3将在至少3,000个基因携带者中测试不同剂量的阿司匹林,以确定低剂量阿司匹林是否有效。

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