This study assessed the metabolic effects of aripiprazole and pimozide in pediatric Tourette syndrome, a neurodevelopmental condition characterized by multiple motor and phonic tics. Patients receiving aripiprazole (n = 25) or pimozide (n = 25) were compared with medication-free patients (n = 25). Body mass index, glycemia, triglyceridemia, and cholesterolemia were monitored at baseline and 12 and 24 months after commencing treatment. The aripiprazole group demonstrated significant increases in cholesterolemia. The pimozide group demonstrated significant increases in glycemia. Both groups demonstrated elevations in triglyceridemia not significantly different from those in unmedicated control subjects. The effect of aripiprazole on cholesterol was apparent after 12 months, but leveled off during year 2 of treatment. Longitudinal studies are required to evaluate the full extent of glycemic alterations with pimozide. Both agents appear relatively safe for use in pediatric Tourette syndrome. These findings will help guide medication selection in patients with specific medical vulnerabilities.

译文

:这项研究评估了阿立哌唑和匹莫西德在小儿抽动秽语综合征中的代谢作用,小儿抽动秽语综合征是一种以多种运动和抽动抽动为特征的神经发育疾病。将接受阿立哌唑(n = 25)或匹莫齐特(n = 25)的患者与无药物治疗的患者(n = 25)进行比较。在基线以及开始治疗后12个月和24个月时监测体重指数,血糖,甘油三酸酯和胆固醇血症。阿立哌唑组显示胆固醇水平显着增加。匹莫齐特组显示血糖显着增加。两组均显示甘油三酯血症的升高与未接受药物治疗的受试者的升高没有显着差异。阿立哌唑对胆固醇的作用在12个月后就很明显,但在治疗的第2年趋于平稳。需要进行纵向研究以评估吡莫司德对血糖变化的全面程度。两种药物在小儿Tourette综合征中使用都相对安全。这些发现将有助于指导具有特定医疗脆弱性的患者选择药物。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录