Elevated allostatic load (AL) index, which is a cumulative measure of biological dysregulations associated with stress exposure, has been demonstrated in patients with psychosis. However, it remains unknown whether a history of childhood trauma (CT) might contribute to elevated AL index in psychosis. Therefore, we aimed to investigate the association between AL index, a history of CT and coping styles in patients with psychotic disorders. Participants were 65 patients with schizophrenia-spectrum disorders and 56 healthy controls (HCs). The AL index was computed based on percentile distributions of 15 biomarkers in HCs. The AL index was significantly higher in patients with psychosis. A history of parental antipathy was associated with elevated AL index in both groups of participants. A history of any categories of CT and sexual abuse were associated with higher AL index only in patients with psychosis. Social diversion (seeking social interactions in case of stressful experiences) mediated the association between sexual abuse and the AL index in the group of patients. There was a significant direct effect of sexual abuse on the AL index (this specific CT was associated with higher AL index). However, indirect effect of sexual trauma on AL through social diversion was opposite to direct effect. Childhood adversities, especially sexual abuse and parental antipathy, might contribute to elevated AL index in patients with psychosis. The effect of sexual abuse on the AL index might be specific to psychosis. Engagement in social interactions in case of stressful situations might alleviate biological dysregulations associated with CT.

译文

:精神病患者已证明,高水平的同种异体负荷(AL)指数是与压力暴露有关的生物学失调的累积量度。但是,尚不清楚儿童创伤史(CT)是否可能导致精神病患者的AL指数升高。因此,我们旨在研究精神病患者的AL指数,CT病史和应对方式之间的关系。参加者有65例精神分裂症-频谱障碍患者和56例健康对照(HCs)。 AL指数是根据HC中15种生物标志物的百分比分布计算得出的。精神病患者的AL指数显着较高。两组参与者的父母反感病史都与AL指数升高有关。任何类型的CT和性虐待史都仅在精神病患者中与较高的AL指数相关。社会转移(在有压力经历的情况下寻求社会互动)介导了患者群体中性虐待与AL指数之间的关联。性虐待对AL指数有显着的直接影响(该特定的CT与较高的AL指数有关)。然而,通过社会转移对AL造成的性创伤的间接影响与直接影响相反。童年时期的逆境,尤其是性虐待和父母的反感,可能会导致精神病患者的AL指数升高。性虐待对AL指数的影响可能是精神病特有的。在有压力的情况下参与社交互动可能会减轻与CT相关的生物学失调。

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