Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.

译文

细菌和癌细胞会因长时间暴露于无效水平的试剂而对一种以上的试剂产生抗药性。这些细胞的抗性是由过表达的外排泵介导的,外排泵具有挤出多种无关化学物质的能力。这篇评论讨论了细菌和癌细胞的多药耐药性(MDR)外排系统的主要类型,并显示了它们之间的特定外排系统与给定的抑制外排的药物之间的相似性,从而使这些细胞再次易受细菌和癌细胞的侵害。他们开发了MDR。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录