BACKGROUND:Angiogenesis is a basic process that enables neoplasms to thrive. Microvessel density (MVD) evaluation is an accepted parameter for assessing the angiogenesis process within a tumor. The aim of the present study has been to assess the number of microcapillaries in both invasive ductal breast cancer with the presence of metastases in regional lymph nodes and in invasive ductal breast cancer without such metastases.
METHODS:The CD34 antigen immunoreactivity level was assessed by immunohistochemistry in both types of invasive ductal breast cancer. Tissue samples were obtained from 40 patients and were divided into two groups according to whether or not there were lymph node metastases.
RESULTS:The patients with lymph node metastases exhibited statistically significantly higher numbers of stained microcapillaries than the patients who did not have lymph node metastases.
CONCLUSION:Thus the number of stained microcapillaries as evaluated by using the CD34 immunoreactivity level seems to be a useful predictor for the development of local lymph node metastases in female invasive ductal breast cancer.
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【The analysis of CD34 antigen immunoreactivity level in invasive ductal breast cancer with respect to the presence of lymph node metastases.].
【关于淋巴结转移的存在，分析浸润性导管癌中CD34抗原的免疫反应水平。】
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背景：血管生成是使肿瘤得以兴旺发展的基本过程。微血管密度（MVD）评估是用于评估肿瘤内血管生成过程的公认参数。本研究的目的是评估在区域性淋巴结中有转移的浸润性导管癌和没有转移的浸润性导管癌中微血管的数量。
方法：采用免疫组织化学方法评估两种浸润性导管癌中CD34抗原的免疫反应水平。从40例患者中获取组织样本，并根据是否有淋巴结转移将其分为两组。
结果：与没有淋巴结转移的患者相比，具有淋巴结转移的患者表现出显着更高的染色微毛细管数量。
结论：因此，通过使用CD34免疫反应水平评估的染色微毛细管数目似乎是女性浸润性导管癌局部淋巴结转移发展的有用预测指标。
方法：采用免疫组织化学方法评估两种浸润性导管癌中CD34抗原的免疫反应水平。从40例患者中获取组织样本，并根据是否有淋巴结转移将其分为两组。
结果：与没有淋巴结转移的患者相比，具有淋巴结转移的患者表现出显着更高的染色微毛细管数量。
结论：因此，通过使用CD34免疫反应水平评估的染色微毛细管数目似乎是女性浸润性导管癌局部淋巴结转移发展的有用预测指标。
