Zebrafish is a common model organism in research and yet, despite its widespread use, anatomical resources for this species are incomplete or lacking in functionality. There remains a need for a single reference resource that integrates user-friendly tools to facilitate the identification of structures, display of reference images, provides data on gene expression, links to relevant literature, and covers the complete range of zebrafish developmental stages. To fulfill this need, we have designed the Zebrafish Anatomy Portal (www.zfap.org), containing annotated three-dimensional images of zebrafish at stages throughout development and adulthood, acquired by optical projection tomography. ZFAP combines functionalities to allow scanning through 3D data sets, searching of images by anatomical terms, predictions of gene expression from literature analysis, and facilitation of the identification of relevant literature through assisted searching of the NCBI PubMed resource. ZFAP provides a highly functional anatomical resource that will aid future education and research in the zebrafish model system.

译文

斑马鱼是研究中常见的模式生物,尽管用途广泛,但该物种的解剖资源不完整或缺乏功能。仍然需要一个单一的参考资源,该资源集成了易于使用的工具,以帮助识别结构,显示参考图像,提供有关基因表达的数据,链接到相关文献并涵盖斑马鱼发育阶段的整个范围。为满足此需求,我们设计了斑马鱼解剖门户网站(www.zfap.org),其中包含斑马鱼在整个发育和成年阶段的带注释的三维图像,这些图像是通过光学投影层析成像技术获得的。 ZFAP结合了各种功能,可以扫描3D数据集,通过解剖学术语搜索图像,通过文献分析预测基因表达,并通过辅助搜索NCBI PubMed资源来促进相关文献的鉴定。 ZFAP提供了功能强大的解剖资源,将有助于斑马鱼模型系统的未来教育和研究。

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