Geriatric depression consists of complex and heterogeneous behaviors unlikely to be caused by a single brain lesion. However, there is evidence that abnormalities in specific brain structures and their interconnections confer vulnerability to the development of late-life depression. Structural magnetic resonance imaging methods can be used to identify and quantify brain abnormalities predisposing to geriatric depression and in prediction of treatment response. This article reviews several techniques, including morphometric approaches, study of white matter hyperintensities, diffusion tensor imaging, magnetization transfer imaging, t2 relaxography, and spectroscopy, that have been used to examine these brain abnormalities with a focus on the type of information obtained by each method as well as each method's limitations. The authors argue that the available methods provide complementary information and that, when combined judiciously, can increase the knowledge gained from neuroimaging findings and conceptually advance the field of geriatric depression.

译文

老年抑郁症由复杂和异质的行为组成,不太可能由单个脑部病变引起。然而,有证据表明,特定大脑结构及其相互联系的异常使人们容易患上晚期抑郁症。结构磁共振成像方法可用于识别和量化易患老年抑郁症的脑部异常,并预测治疗反应。本文回顾了几种技术,包括形态计量学方法,白质高强度研究,扩散张量成像,磁化转移成像,t2弛豫成像和光谱学,这些技术已用于检查这些大脑异常,重点是获得的信息类型通过每种方法以及每种方法的局限性。作者认为,可用的方法提供了补充信息,并且如果明智地结合在一起,可以增加从神经影像学发现中获得的知识,并在概念上推进老年抑郁症领域。

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