Over an 8 year period, 170 patients with multiple sclerosis (MS) and 134 healthy controls were assessed at monthly intervals in order to ascertain environmental factors which might be important in producing exacerbation or progression of the illness, and to compare the frequency of common viral infections in the two groups. During cumulative periods designated "at risk" (2 weeks before the onset of infection until 5 weeks afterwards) annual exacerbation rates were almost 3-fold greater than those during periods not at risk. Approximately 9% of infections were temporally related to exacerbations, whereas 27% of exacerbations were related to infections. Frequency of common infections was approximately 20-50% less in MS patients than controls; it was progressively less in those with greater disability. Even in minimally disabled patients with similar potential for infectious contacts, the infection rate was significantly less than in controls, suggesting that MS patients could have superior immune defences against common viruses.

译文

在8年的时间里,每月对170名多发性硬化症 (MS) 患者和134名健康对照者进行评估,以确定可能对疾病恶化或进展很重要的环境因素,并比较两组中常见病毒感染的频率。在指定为 “处于危险中” 的累积期间 (感染发作前2周至之后5周),年恶化率几乎是无危险期间的3倍。大约9% 的感染在时间上与恶化有关,而27% 的恶化与感染有关。MS患者的常见感染频率比对照组低约20-50%; 残疾程度较高的患者逐渐减少。即使在具有类似感染接触潜力的最小残疾患者中,感染率也明显低于对照组,这表明MS患者可以对普通病毒具有出色的免疫防御能力。

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