The goal of the study was to elucidate the relationship between serum circulating brain-derived neurotrophic factor (BDNF) and body weight reduction via lifestyle modification and behavior therapy in obese non-diabetic patients with chronic schizophrenia. Thirty-three obese non-diabetic subjects with schizophrenia treated with stable antipsychotic medication in a day-care unit for at least 3 months were recruited. Thirty age-, body weight-matched subjects without psychiatric disorders were enrolled as controls. All participants underwent a 10-week weight reduction program, including lifestyle modification, psychosocial treatment, behavior therapy and exercise in the day-care unit. Blood biochemistry, serum BDNF, adipokine (adiponectin), inflammatory markers (C-reactive protein, tumor necrosis factor-alpha and interleukin-6) and oral glucose tolerance test were evaluated before and after the program. Serum BDNF concentrations were significantly lower among patients with schizophrenia compared to control subjects. Serum BDNF levels were significantly increased following the weight reduction program. Elevations in serum BDNF levels were positively correlated with body weight and body mass index reduction. Altogether, our results demonstrate that a non-pharmacological weight reduction program effectively reduces body weight with significant elevation of serum BDNF levels in obese non-diabetic patients with schizophrenia.

译文

该研究的目的是阐明肥胖的非糖尿病慢性精神分裂症患者血清循环脑源性神经营养因子 (BDNF) 与通过改变生活方式和行为疗法减轻体重之间的关系。招募了33名肥胖的非糖尿病精神分裂症患者,他们在日托病房接受了稳定的抗精神病药物治疗至少3个月。纳入了30名年龄,体重匹配的无精神疾病的受试者作为对照。所有参与者都接受了为期10周的减肥计划,包括改变生活方式,心理社会治疗,行为治疗和在日托单元进行锻炼。方案前后分别进行血生化、血清BDNF、脂肪因子 (脂联素) 、炎症标志物 (C-反应蛋白、肿瘤坏死因子-α 和interleukin-6) 及口服葡萄糖耐量试验。与对照组相比,精神分裂症患者的血清BDNF浓度显着降低。减肥计划后,血清BDNF水平显着增加。血清BDNF水平升高与体重和体重指数降低呈正相关。总之,我们的结果表明,在肥胖的非糖尿病精神分裂症患者中,非药物减肥计划可有效降低体重,并显着提高血清BDNF水平。

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