Considering the existing conflicts about how an elevated body mass index (BMI) affects fertility, this study had the objective of evaluating the impact of overweight and obesity on the results of IVF/ICSI (in-vitro fertilisation/intracytoplasmatic sperm injection) performed at the Human Reproduction Centre of Faculdade de Medicina do ABC. Retrospective data from 208 IVF cycles of 191 women, performed at our laboratory from February through June, 2008, were used to calculate their BMI. On the basis of the results, the patients were divided into two groups: Group 1: BMI <25 kg/m(2) and Group 2: BMI  ≥ 25 kg/m(2). Of the 208 cycles, 137 were from patients with BMI <25 kg/m(2) and 71 cycles from patients with BMI  ≥ 25 kg/m(2). Patients' ages and the number of cycles with gonadotrophin-releasing hormone agonist and antagonist were similar in both groups. The doses of follicle-stimulating hormone used for ovarian induction per cycle, the number of retrieved oocytes, fertilisation rate, embryo quality and number of transferred and frozen embryos, the hyperstimulation, pregnancy rates, miscarriage rate and live birth rates showed no statistically significant differences. BMI does not appear to be a good parameter for the definition of IVF success. The association with other methodologies may produce more consistent data about body composition and its impact on fertility.

译文

考虑到关于体重指数 (BMI) 升高如何影响生育能力的现有冲突,这项研究的目的是评估超重和肥胖对在aculdade de Medicina do ABC人类生殖中心进行的IVF/ICSI (体外受精/胞浆内精子注射) 结果的影响。回顾性数据来自191名妇女的208个IVF周期,从2月到2008年6月在我们的实验室进行,用于计算他们的BMI。根据结果将患者分为两组: 第一组: bmi   <25千克/m(2) 和第二组: bmi   ≥ 25千克/m(2)。在208个周期中,137个周期来自bmi   <25千克/m(2) 的患者,71个周期来自bmi   ≥ 25千克/m(2) 的患者。两组患者的年龄和使用促性腺激素释放激素激动剂和拮抗剂的周期数相似。每个周期用于卵巢诱导的促卵泡激素的剂量,卵母细胞的回收数量,受精率,胚胎质量以及转移和冷冻胚胎的数量,过度刺激,妊娠率,流产率和活产率均无统计学差异。BMI似乎不是定义IVF成功的良好参数。与其他方法的关联可能会产生有关身体成分及其对生育力影响的更一致的数据。

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