Accumulated evidence indicates chronic systemic injection of D-galactose mimics aging progress induced by oxidative stress. We addressed whether memory impairment in this model was associated with the cholinergic septohippocampal degeneration. Rats injected with D-galactose for 6 weeks showed impairment of spatial learning and memory as measured by the water maze test. Correspondingly, anti-choline acetyltransferase immunohistochemistry demonstrated a severe loss of cholinergic terminals in the hippocampus accompanied by a mild cholinergic neuronal atrophy and loss in the medial septum and the nucleus of the vertical limb of the diagonal band of Broca. A major synaptic degeneration in the hippocampus was confirmed by ultrastructural analysis. These findings provide neuropathological evidence for rodents with chronic injection of D-galactose as a promising model for brain aging and age-related neurodegeneration.

译文

积累的证据表明,慢性全身注射D-半乳糖模拟氧化应激诱导的衰老进程。我们讨论了该模型中的记忆障碍是否与胆碱能海马变性有关。通过水迷宫测试,注射D-半乳糖6周的大鼠显示出空间学习和记忆受损。相应地,抗胆碱乙酰转移酶免疫组织化学表明,海马中胆碱能末端严重丢失,并伴有轻度胆碱能神经元萎缩,并在Broca对角带的内侧间隔和垂直肢体的核中丢失。通过超微结构分析证实了海马的主要突触变性。这些发现为慢性注射D-半乳糖作为大脑衰老和与年龄相关的神经变性的有希望的模型的啮齿动物提供了神经病理学证据。

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