This report describes the measurement properties of the Personal and Social Performance scale (PSP), a clinician-reported measure of severity of personal and social dysfunction, in an outpatient population with stabilized schizophrenia. Pooled data from two similar antipsychotic clinical studies were analyzed (n=411). The PSP showed good test-retest reliability (intraclass correlation coefficient=0.79). The PSP was more highly correlated with the Strauss-Carpenter Level of Function, an instrument measuring a similar construct, than the Positive and Negative Syndrome Scale, an instrument measuring a different construct. There was a statistically significant difference between mean PSP scores in subjects grouped by their severity rating on the Clinical Global Impression-Severity (CGI-S) (mild or less versus at least moderate), indicating the ability to discriminate between known groups. Effect sizes for mean change in the PSP based on 1-category improvement (0.72) or worsening (-0.88) versus no change in the CGI-S were moderate to large, demonstrating the ability to detect change. Estimates of between-group minimum important difference suggest that a 7-point improvement in the PSP may be clinically meaningful in a clinical trial setting. Initial reliability and validity assessments suggest the PSP may be a useful measure of social functioning in patients with stable schizophrenia.

译文

本报告描述了个人和社会绩效量表 (PSP) 的测量特性,PSP是临床医生报告的对稳定精神分裂症门诊患者个人和社会功能障碍严重程度的测量。分析了来自两个相似的抗精神病药物临床研究的合并数据 (n = 411)。PSP显示出良好的重测信度 (类内相关系数 = 0.79)。PSP与测量类似结构的仪器Strauss-Carpenter功能水平 (一种测量类似结构的仪器) 的相关性更高,而与测量不同结构的正负综合症量表 (一种测量不同结构的仪器) 的相关性更高。在按临床总体印象严重程度 (cgi-s) 的严重程度分组的受试者中,平均PSP得分之间存在统计学上的显着差异 (轻度或以下与至少中度),表明可以区分已知组。基于1-类别改善 (0.72) 或恶化 (-0.88) 与cgi-s无变化的PSP的平均变化的效应大小是中等到大的,表明检测变化的能力。组间最小重要差异的估计表明,在临床试验环境中,PSP的7点改善可能具有临床意义。最初的信度和效度评估表明,PSP可能是稳定精神分裂症患者社交功能的有用指标。

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