P strains of Drosophila are distinguished from M strains by having P elements in their genomes and also by having the P cytotype, a maternally inherited condition that strongly represses P-element-induced hybrid dysgenesis. The P cytotype is associated with P elements inserted near the left telomere of the X chromosome. Repression by the telomeric P elements TP5 and TP6 is significantly enhanced when these elements are crossed into M' strains, which, like P strains, carry P elements, but have little or no ability to repress dysgenesis. The telomeric and M' P elements must coexist in females for this enhanced repression ability to develop. However, once established, it is transmitted maternally to the immediate offspring independently of the telomeric P elements themselves. Females that carry a telomeric P element but that do not carry M' P elements may also transmit an ability to repress dysgenesis to their offspring independently of the telomeric P element. Cytotype regulation therefore involves a maternally transmissible product of telomeric P elements that can interact synergistically with products from paternally inherited M' P elements. This synergism between TP and M' P elements also appears to persist for at least one generation after the TP has been removed from the genotype.

译文

果蝇的P株与M株的区别在于其基因组中具有P元素,并且还具有P细胞型,这是一种强烈抑制P元素诱导的杂种发育不全的母系遗传性疾病。P细胞类型与插入X染色体左端粒附近的P元件有关。当端粒P元素TP5和TP6杂交成M' 菌株时,它们的抑制作用显着增强,M' 菌株与P菌株一样,带有P元素,但几乎没有抑制发育不全的能力。端粒和m'p元素必须在雌性中共存,以增强这种抑制能力。但是,一旦建立,它就会独立于端粒P元素本身而通过母系传播给直接的后代。携带端粒P元素但不携带m'p元素的雌性也可能独立于端粒P元素向其后代传递抑制发育不全的能力。因此,细胞类型调节涉及端粒P元件的母体可传播产物,该产物可以与父系遗传的m'p元件的产物协同相互作用。TP和m'p元素之间的这种协同作用在TP从基因型中去除后似乎也持续了至少一代。

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