A variety of experimental models indicate that programmed cell death, or apoptosis, of lymphocytes is a key mechanism in the homeostatic regulation of immunity. Apoptosis is important in early B- and T-cell development to delete cells with nonfunctional antigen receptors, and is also critical for censoring self-reactive cells at the immature lymphocyte stage and at various stages after lymphocytes reach maturity. In this article we focus on the role of the apoptosis regulatory gene bcl-x in controlling survival during lymphocyte development and following B- and T-cell activation. Interesting parallels are observed for bcl-x expression between the B- and T-lineages. The available data also indicate that bcl-x and bcl-2 are expressed in reciprocal patterns during the lifespan of a lymphocyte, suggesting unique regulatory roles for these two survival proteins.

译文

多种实验模型表明,淋巴细胞的程序性细胞死亡或凋亡是免疫稳态调节的关键机制。凋亡在早期b细胞和T细胞发育中很重要,可以删除具有无功能抗原受体的细胞,并且对于在未成熟淋巴细胞阶段和淋巴细胞成熟后的各个阶段审查自我反应细胞也至关重要。在本文中,我们专注于凋亡调节基因bcl-x在控制淋巴细胞发育期间以及b细胞和T细胞活化后的存活中的作用。在B谱系和T谱系之间观察到bcl-x表达的有趣的相似之处。现有数据还表明,bcl-x和bcl-2在淋巴细胞的寿命期间以相互模式表达,这表明这两种存活蛋白具有独特的调节作用。

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