Over 3500 patients with recent onset inflammatory polyarthritis (IP) have been recruited by the Norfolk Arthritis Register (NOAR) since 1990. Longitudinal data from this cohort have been used to examine the prevalence and predictors of remission, functional disability, radiological outcome, cardiovascular mortality and co-morbidity and the development of non-Hodgkin's lymphoma. Rheumatoid factor titre, high baseline C-reactive protein and high baseline HAQ score are all predictors of a poor outcome. There is a strong association between possession of the shared epitope and the development of erosions. Patients who satisfy the American College of Rheumatology criteria for rheumatoid arthritis (RA) have a worse prognosis than those who do not. However, it appears that these patients are a poorly defined subset of all those with IP rather than having an entirely separate disease entity. New statistical techniques offer exciting possibilities for using longitudinal datasets such as NOAR to explore the long-term effects of treatment in IP and RA.

译文

诺福克关节炎注册 (NOAR) 1990年招募了3500多名近期发病的炎症性多关节炎 (IP) 患者。来自该队列的纵向数据已用于检查缓解,功能障碍,放射学结果,心血管死亡率和合并症的患病率和预测因素以及非霍奇金淋巴瘤的发展。类风湿因子滴度,高基线C反应蛋白和高基线HAQ评分都是不良预后的预测指标。拥有共同的表位与侵蚀的发展之间存在很强的联系。符合美国风湿病学会类风湿关节炎 (RA) 标准的患者的预后比不符合该标准的患者差。然而,这些患者似乎是所有IP患者中定义不明确的子集,而不是具有完全独立的疾病实体。新的统计技术为使用纵向数据集 (例如NOAR) 探索IP和RA治疗的长期影响提供了令人兴奋的可能性。

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