The Research Domain Criteria (RDoC) initiative promoted by the National Institute of Mental Health emphasizes a dimensional approach to psychopathology that is agnostic to DSM diagnosis. The RDoC project offers exciting possibilities for advancing research aimed at preventing psychopathology. However, prevention has historically been defined using diagnostic status, requiring the field to redefine what constitutes prevention using an RDoC approach. This article outlines new criteria for prevention in the RDoC context and provides guidance for implementing these criteria. We also describe the role of prevention-mechanism trials that examine whether preventive interventions change proximal etiological mechanisms known to be associated with psychopathology. We hope that these modified criteria and recommendations will stimulate new possibilities for prevention research that will advance the field.

译文

由美国国家精神卫生研究所推动的研究领域标准 (RDoC) 倡议强调了一种与DSM诊断无关的心理病理学维度方法。RDoC项目为推进旨在预防精神病理学的研究提供了令人兴奋的可能性。但是,历史上使用诊断状态定义了预防,要求该领域使用RDoC方法重新定义构成预防的内容。本文概述了RDoC背景下的新预防标准,并为实施这些标准提供了指导。我们还描述了预防机制试验的作用,该试验检查了预防干预措施是否改变了已知与精神病理学相关的近端病因机制。我们希望,这些经修改的标准和建议将激发预防研究的新可能性,从而推动这一领域的发展。

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