Both ranitidine and metoclopramide produce neuropsychiatric side effects. Concomitant use of these drugs preoperatively may produce adverse behavioral and emotional changes. Therefore, in 123 unpremedicated patients undergoing tubal occlusion, behavior, cognitive function, and affect were studied before and after a 2-min intravenous injection of placebo (n = 30), ranitidine 50 mg (n = 32), metoclopramide 10 mg (n = 30), or both ranitidine 50 mg and metoclopramide 10 mg (n = 31). Cognitive function was evaluated by the responses to 11 statements devised to assess attitude toward anesthesia and surgery. Affect was assessed by the word chosen out of 11 word-pairs as best describing the feelings at the time. After ranitidine injection, one patient seemed restless and five seemed drowsy. The changes were associated with subjective feelings of agitation (P < 0.05) and restlessness (P < 0.05). After metoclopramide injection, 6 (20%) developed akathisia, 13 (43.3%) seemed restless, and 8 (26.7%) seemed drowsy. The changes were associated with subjective sensation of jumpiness (P < 0.01) and discomfort (P < 0.05). When both ranitidine and metoclopramide were injected, 10 (32.3%) developed akathisia, 4 (12.4%) seemed restless, and 11 (35.5%) seemed drowsy. The changes were associated with subjective feelings of agitation (P < 0.05), jumpiness (P < 0.05), restlessness (P < 0.01), and upset (P < 0.05). Akathisia, a side effect of metoclopramide, seemed to be more prominent when ranitidine was added.

译文

雷尼替丁和甲托普胺都产生神经精神副作用。术前同时使用这些药物可能会产生不良的行为和情绪变化。因此,在123例未接受输卵管阻塞的患者中,在静脉注射2分钟安慰剂 (n = 30),雷尼替丁50 mg (n = 32),甲托普胺10 mg (n = 30) 之前和之后研究了行为,认知功能和情感。或雷尼替丁50 mg和甲托普胺10 mg (n = 31)。通过对11条旨在评估对麻醉和手术态度的陈述的反应来评估认知功能。情感是通过从11个单词对中选择的单词来评估的,该单词最能描述当时的感受。雷尼替丁注射后,一名患者似乎焦躁不安,五名患者似乎昏昏欲睡。这些变化与主观躁动 (P < 0.05) 和躁动 (P < 0.05) 有关。注射甲托普胺后,6 (20%) 出现静坐不能,13 (43.3%) 似乎不安,8 (26.7%) 似乎昏昏欲睡。这些变化与主观感觉跳跃 (P < 0.01) 和不适 (P < 0.05) 有关。同时注射雷尼替丁和甲托普胺时,10 (32.3%) 出现静坐不能,4 (12.4%) 似乎不安,11 (35.5%) 似乎昏昏欲睡。这些变化与主观躁动感 (P <0.05),跳跃感 (P <0.05),躁动感 (P < 0.01) 和心烦感 (P < 0.05) 有关。静坐不能,甲托普胺的副作用,在添加雷尼替丁时似乎更突出。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录