The effects of oral omeprazole and oral ranitidine on gastric fluid volume and pH were compared in 95 elective surgical patients, randomly assigned to one of three groups. The patients received either 80 mg of omeprazole or 300 mg of ranitidine orally at 6.00 on the morning of surgery. One third of the patients received no antacid therapy. Following induction, a no. 18 nasogastric tube was passed into the stomach and all available gastric fluid was aspirated. pH and volumes were measured. In the omeprazole- and ranitidine-treated groups, the mean pH was > 5.4 after induction, at completion of surgery and 1 h after operation, although at least one patient in both groups had pH < 2.5. The volumes of gastric aspirates were reduced equally by both drugs. Two patients in the omeprazole group, none in the ranitidine group and eight in the control group (26%) had pH < 2.5 with volume > 25 ml at induction. Both drugs appeared to be effective in reducing the volume of intragastric fluid and acidity to acceptable values.

译文

比较了95例择期手术患者口服奥美拉唑和口服雷尼替丁对胃液量和pH的影响,随机分为三组之一。患者在手术的早晨6.00时口服80 mg奥美拉唑或300 mg雷尼替丁。三分之一的患者没有接受抗酸治疗。诱导后,将18号鼻胃管送入胃中,并抽吸所有可用的胃液。测量ph值和体积。在奥美拉唑和雷尼替丁治疗组中,诱导后、手术完成时以及手术后1小时的平均pH> 5.4,尽管两组中至少有一名患者的pH <2.5。两种药物均减少了胃抽吸物的体积。奥美拉唑组2例,雷尼替丁组无一例,对照组8例 (26%) 诱导时pH <2.5,体积> 25毫升。两种药物似乎都可以有效地将胃内液的体积和酸度降低到可接受的值。

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