Morphine and tubocurarine may release histamine by direct mast cell degranulation which may result in systemic effects such as cutaneous flushing, local wheal and flare formation and hypotension. This randomised, double-blind study examined whether preoperative combined oral terfenadine (60 mg) and ranitidine (150 mg) attenuates the reduction in blood pressure and cutaneous flushing after the administration of tubocurarine and morphine in 60 patients undergoing elective gynaecological surgery. In addition, investigation was made of whether tubocurarine and morphine cause a significant decrease in gastric pH in comparison to the nonhistamine-releasing agents fentanyl and vecuronium. Patients were randomly assigned to one of three groups receiving either pre-operative terfenadine and ranitidine and intra-operative tubocurarine and morphine (group A); pre-operative placebo and intra-operative tubocurarine and morphine (group B); pre-operative placebo and intra-operative fentanyl and vecuronium (group C). Compared to group B, group A had less hypotension and tachycardia but no significant decrease in cutaneous flushing immediately following morphine and tubocurarine (p > 0.05). There were no significant differences in haemodynamic changes between the groups A and C. In those patients not pretreated with terfenadine and ranitidine (groups B and C), gastric pH decreased between 5 and 10 min following bolus administration of morphine and tubocurarine (group B), whereas patients receiving fentanyl and vecuronium (group C) had an increase in gastric pH. This suggests that histamine release following administration of morphine and tubocurarine is sufficient to increase gastric acidity.(ABSTRACT TRUNCATED AT 250 WORDS)

译文

吗啡和tubocurarine可通过直接肥大细胞脱颗粒释放组胺,这可能导致全身作用,例如皮肤潮红,局部风团和耀斑形成和低血压。这项随机,双盲研究检查了60例接受择期妇科手术的患者,术前联合口服特非那定 (60 mg) 和雷尼替丁 (150 mg) 是否减轻了给予tubocurarine和吗啡后血压和皮肤潮红的降低。此外,与非组胺释放剂芬太尼和维库溴铵相比,进行了研究,是否与吗啡和吗啡引起胃pH显着降低。患者被随机分配到三组之一,分别接受术前特非那定和雷尼替丁以及术中tubocurarine和吗啡 (A组); 术前安慰剂和术中tubocurarine和吗啡 (B组); 术前安慰剂和术中芬太尼和维库溴铵 (C组)。与B组相比,A组的低血压和心动过速较少,但吗啡和小管碱后即刻皮肤潮红无明显减少 (p> 0.05)。A组和C组之间的血液动力学变化没有显着差异。在未接受特非那定和雷尼替丁预处理的患者 (B和C组) 中,在推注吗啡和tubocurarine后5至10分钟内胃ph值降低 (B组),而接受芬太尼和维库溴铵的患者 (C组) 胃ph值升高。这表明吗啡和tubocurarine给药后的组胺释放足以增加胃酸度。(摘要截短于250字)

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录