The effects of a ranitidine-zinc complex and ranitidine alone were compared in three different experimental models (pyloric ligation, ethanol and indomethacin) of gastric ulceration in the rat. In the pyloric ligation model, the ranitidine-zinc complex (50, 100 and 150 mg/kg p.o.) showed antiulcerogenic activity similar to that observed with equimolar doses of ranitidine (35, 70 and 105 mg/kg p.o.). Both the ranitidine-zinc complex and ranitidine significantly reduced (p < 0.05) gastric acid secretion in a dose-dependent manner. The protective effect of the ranitidine-zinc complex (100 and 150 mg/kg p.o.) against gastric damage developing after p.o. administration of absolute ethanol or indomethacin was enhanced (p < 0.05) with respect to that obtained with equimolar doses of ranitidine (70 and 105 mg/kg p.o.). The presence of zinc in the ranitidine-zinc complex does not interfere with the antisecretory effects of ranitidine on the gastric mucosa, while it confers an additional cytoprotective action to the final compound.

译文

在大鼠胃溃疡的三种不同实验模型 (幽门结扎,乙醇和吲哚美辛) 中比较了雷尼替丁-锌复合物和单独雷尼替丁的作用。在幽门结扎模型中,雷尼替丁-锌复合物 (50、100和150 mg/kg p.o.) 表现出与等摩尔剂量雷尼替丁 (35、70和105 mg/kg p.o.) 相似的抗溃疡活性。雷尼替丁-锌复合物和雷尼替丁均以剂量依赖性方式显著减少 (p < 0.05) 胃酸分泌。雷尼替丁-锌复合物 (100和150 mg/kg p.o.) 对p.o.后发生的胃损伤的保护作用。相对于等摩尔剂量的雷尼替丁 (70和105 mg/kg p.o.) 获得的无水乙醇或消炎痛的给药增强 (p <0.05)。雷尼替丁-锌复合物中锌的存在不会干扰雷尼替丁对胃粘膜的抗分泌作用,同时赋予最终化合物额外的细胞保护作用。

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