Few reports exist on allergic reactions to ranitidine. We present a case of bronchospastic reaction to ranitidine occurred during a drug challenge test. After administration of a therapeutic dose of ranitidine, the patient showed dyspnea, cough and bronchospasm in all the lung fields. Personal respiratory background was negative for respiratory disease and asthma. On reviewing the literature we found no reports of bronchospastic reaction to ranitidine. Quickness and the clinical characteristics of the adverse reaction suggest a pathogenic mechanism of immediate-type hypersensitivity.

译文

关于雷尼替丁过敏反应的报道很少。我们介绍了在药物激发试验期间发生的对雷尼替丁的支气管痉挛反应的情况。给予治疗剂量的雷尼替丁后,患者在所有肺野均表现出呼吸困难,咳嗽和支气管痉挛。个人呼吸背景对呼吸系统疾病和哮喘阴性。在回顾文献时,我们没有发现雷尼替丁发生支气管痉挛反应的报道。快速反应和不良反应的临床特征提示了即刻型超敏反应的致病机制。

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