The relative effect of glucose and lipids on whole-body protein-metabolism kinetics was assessed in seven infants undergoing parenteral feeding. Protein intake was kept constant and nonprotein energy was either provided as glucose alone or as an isoenergetic glucose-lipid mixture according to a randomized crossover trial. Protein metabolism and energy-substrate utilization were assessed by a primed, constant L-[13C]leucine infusion, combined with indirect calorimetry. There was a significant difference in the pattern of energy-substrate utilization according to regime. Protein turnover (11.3 +/- 0.7 vs 9.8 +/- 0.4 g.kg-1.d-1; P less than 0.05), protein breakdown (8.4 +/- 0.6 vs 7.1 +/- 0.4 g.kg-1.d-1; P less than 0.05), and amino acid oxidation rates (2.7 +/- 0.4 vs 1.4 +/- 0.5 g.kg-1.d-1; P less than 0.05) were higher for the glucose than the glucose-lipid treatment, whereas protein-synthesis rates did not significantly differ. These results suggest that the nature of energy substrates delivered to parenterally fed infants may affect protein metabolism.

译文

在接受胃肠外喂养的7名婴儿中评估了葡萄糖和脂质对全身蛋白质代谢动力学的相对影响。根据一项随机交叉试验,蛋白质摄入量保持恒定,非蛋白质能量既可以单独作为葡萄糖提供,也可以作为同能葡萄糖-脂质混合物提供。通过定量的L-[13C] 亮氨酸输注评估蛋白质代谢和能量底物利用,结合间接量热法。根据方案,能量-底物利用模式存在显著差异。蛋白质更新 (11.3 +/- 0.7 vs 9.8 +/- 0.4g。kg-1.d-1; P小于0.05),蛋白质分解 (8.4 +/- 0.6 vs 7.1 +/- 0.4g。kg-1.d-1; P小于0.05) 和氨基酸氧化速率 (2.7 +/- 0.4 vs 1.4 +/- 0.5g。kg-1.d-1; P小于0.05) 的葡萄糖比糖脂处理高,而蛋白质合成速率没有显著差异。这些结果表明,给肠胃外喂养婴儿的能量底物的性质可能会影响蛋白质代谢。

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