Aquaporins are a family of transmembrane proteins permeable to water. In mammals, they are subdivided into classical aquaporins that are permeable to water; aquaglyceroporins that are permeable to water, glycerol and urea; peroxiporins that facilitate the diffusion of H2O2 through cell membranes; and so called unorthodox aquaporins. Aquaporins ensure important physiological functions in both exocrine and endocrine pancreas. Indeed, they are involved in pancreatic fluid secretion and insulin secretion. Modification of aquaporin expression and/or subcellular localization may be involved in the pathogenesis of pancreatic insufficiencies, diabetes and pancreatic cancer. Aquaporins may represent useful drug targets for the treatment of pathophysiological conditions affecting pancreatic function, and/or diagnostic/predictive biomarker for pancreatic cancer. This review summarizes the current knowledge related to the involvement of aquaporins in the pancreas physiology and physiopathology.

译文

水通道蛋白是一类可渗透水的跨膜蛋白。在哺乳动物中,它们被细分为对水可渗透的经典水通道蛋白; 对水,甘油和尿素可渗透的水甘油孔蛋白; 促进H2O2通过细胞膜扩散的peroxiporins; 以及所谓的非正统水通道蛋白。水通道蛋白可确保外分泌和内分泌胰腺的重要生理功能。事实上,它们参与胰液分泌和胰岛素分泌。水通道蛋白表达和/或亚细胞定位的修饰可能与胰腺不足,糖尿病和胰腺癌的发病机理有关。水通道蛋白可能是治疗影响胰腺功能的病理生理状况和/或胰腺癌的诊断/预测生物标志物的有用药物靶标。这篇综述总结了与水通道蛋白参与胰腺生理学和生病理相关的最新知识。

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