Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in patients who are otherwise healthy and present with thrombocytopenia with normal red cells and leukocytes. ITP is a diagnosis of exclusion and is in origin heterogeneous. The unknown etiology and the lack of clinical data from controlled prospective studies are reasons for controversies in diagnosis and management. Study endpoints traditionally include the velocity of platelet increase after drug intervention or observation, although a rapid elevation of the platelet count is of questionable clinical value. Evaluation of other endpoints is needed.

译文

特发性血小板减少性紫癜 (ITP) 是健康且伴有正常红细胞和白细胞的血小板减少症患者的出血性疾病。ITP是排除的诊断,并且起源于异质性。未知的病因和缺乏对照前瞻性研究的临床数据是诊断和治疗争议的原因。传统上,研究终点包括药物干预或观察后血小板增加的速度,尽管血小板计数的快速升高具有可疑的临床价值。需要评估其他端点。

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