UNLABELLED:The goal of this study was to measure regional pulmonary perfusion using SPECT and transmission tomography for attenuation correction and density measurements.

METHODS:Regional pulmonary perfusion was studied after intravenous injection of radiolabeled particles in 10 supine healthy volunteers using SPECT. Transmission tomography was used to correct for attenuation, measure lung density and delineate the lungs. The effects of attenuation correction on pulmonary perfusion gradients were investigated.

RESULTS:In perfusion measurements not corrected for attenuation, we found significant perfusion gradients in the direction of gravity but also significant gradients at isogravitational level. After correction for attenuation, the gravitational gradient was significantly greater than before correction, and gradients at isogravitational level were no longer observed. Perfusion in the ventral lung zone was half of that in the dorsal lung zone. Mean lung density was 0.28 +/- 0.03 g/ml, and density showed a significant increase in the direction of gravity and at isogravitational level.

CONCLUSION:We found that SPECT perfusion studies of the lung not corrected for attenuation gave a false impression of nongravitational gradients and underestimate the gradient that is gravity-dependent. Transmission tomography, used for attenuation correction, also quantifies lung density and shows gravity dependent and nondependent density gradients.

译文

未标记 : 本研究的目的是使用SPECT和透射断层扫描来测量局部肺灌注,以进行衰减校正和密度测量。
方法 : 使用SPECT在10名仰卧健康志愿者中静脉注射放射性标记颗粒后研究了局部肺灌注。透射断层扫描用于校正衰减,测量肺密度并描绘肺。研究了衰减校正对肺灌注梯度的影响。
结果 : 在未校正衰减的灌注测量中,我们发现在重力方向上有明显的灌注梯度,但在等重力水平上也有明显的梯度。校正衰减后,重力梯度明显大于校正前,并且不再观察到等重力水平的梯度。腹侧肺区的灌注是背肺区的一半。平均肺密度为0.28/- 0.03 g/ml,并且密度显示重力方向和等重力水平显着增加。
结论 : 我们发现,未校正衰减的肺部SPECT灌注研究给人以非重力梯度的错误印象,并低估了重力依赖性的梯度。用于衰减校正的透射断层扫描还可以量化肺密度,并显示重力依赖性和非依赖性密度梯度。

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