Esophageal squamous cell carcinoma is the sixth most common cancer in the developing world. The aggressive nature of esophageal squamous cell carcinoma, its tendency for relapse, and the poor survival prospects of patients diagnosed at advanced stages, represent a pressing need for the development of new therapies for this disease. Chronic inflammation is known to have a causal link to cancer pre-disposition. Nuclear factor kappa B and signal transducer and activator of transcription 3 are transcription factors which regulate immunity and inflammation and are emerging as key regulators of tumor initiation, progression, and metastasis. Although these pro-inflammatory factors in esophageal squamous cell carcinoma have been well-characterized with reference to protein-coding targets, their functional interactions with non-coding RNAs have only recently been gaining attention. Non-coding RNAs, especially microRNAs and long non-coding RNAs demonstrate potential as biomarkers and alternative therapeutic targets. In this review, we summarize the recent literature and concepts on non-coding RNAs that are regulated by/regulate nuclear factor kappa B and signal transducer and activator of transcription 3 in esophageal cancer progression. We also discuss how these recent discoveries can pave way for future therapeutic options to treat esophageal squamous cell carcinoma.

译文

食管鳞状细胞癌是发展中世界第六大最常见的癌症。食管鳞状细胞癌的侵袭性,复发的趋势以及被诊断为晚期患者的生存前景不佳,迫切需要开发针对该疾病的新疗法。已知慢性炎症与癌症倾向有因果关系。核因子 κ B和信号转导和转录激活子3是调节免疫和炎症的转录因子,并已成为肿瘤发生,进展和转移的关键调节剂。尽管食管鳞状细胞癌中的这些促炎因子已在蛋白质编码靶标方面得到了很好的表征,但它们与非编码rna的功能相互作用直到最近才受到关注。非编码rna,尤其是microrna和长型非编码rna显示出作为生物标志物和替代治疗靶点的潜力。在这篇综述中,我们总结了有关非编码rna的最新文献和概念,这些非编码rna受/调节核因子 κ B和信号转导子和转录激活子3在食管癌进展中的调控。我们还讨论了这些最新发现如何为将来治疗食管鳞状细胞癌的治疗选择铺平道路。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录