Surface-associated microbial communities in many cases display dynamic developmental patterns. Model biofilms formed by Pseudomonas aeruginosa and Pseudomonas putida in laboratory flow-chamber setups represent examples of such behaviour. Dependent on the experimental conditions the bacteria in these model biofilms develop characteristic multicellular structures through a series of distinct steps where cellular migration plays an important role. Despite the appearance of these characteristic developmental patterns in the model biofilms the available evidence suggest that the biofilm forming organisms do not possess comprehensive genetic programs for biofilm development. Instead the bacteria appear to have evolved a number of different mechanisms to optimize surface colonization, of which they express a subset in response to the prevailing environmental conditions. These mechanisms include the ability to regulate cellular adhesiveness and migration in response to micro-environmental signals including those secreted by the bacteria themselves.

译文

表面相关微生物群落在许多情况下显示出动态的发育模式。在实验室流动室设置中,铜绿假单胞菌和恶臭假单胞菌形成的模型生物膜代表了这种行为的例子。根据实验条件,这些模型生物膜中的细菌通过一系列不同的步骤发展出特征性的多细胞结构,其中细胞迁移起着重要作用。尽管在模型生物膜中出现了这些特征性的发育模式,但现有证据表明,形成生物膜的生物不具备用于生物膜发育的综合遗传程序。相反,细菌似乎已经进化出许多不同的机制来优化表面定植,它们表达了对当前环境条件的响应。这些机制包括响应微环境信号 (包括细菌本身分泌的信号) 调节细胞粘附性和迁移的能力。

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