Plasminogen activator inhibitor-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily, which inactivates tissue plasminogen activator (tPA); therefore, increased level of PAI-1 antigen counteracts the anticoagulant effect of tPA and facilitates the fibrin clot formation. Plasma PAI-1 antigen and activity levels are associated with increased body mass index and with features of the insulin resistance syndrome like obesity and diabetes. Visceral adipose tissue produces more PAI-1 than subcutaneous adipose tissue: This increased production of PAI-1 from the visceral adipose tissue is one important link between visceral obesity and cardiovascular disease. Besides visceral adipose tissue, there is mounting evidence that epicardial adipose tissue may be an important source of PAI-1, especially in patients with type 2 diabetes.

译文

纤溶酶原激活物抑制剂-1 (PAI-1) 是丝氨酸蛋白酶抑制剂 (serpin) 超家族的成员,其使组织纤溶酶原激活物 (tPA) 失活; 因此,PAI-1抗原水平的升高抵消了tPA的抗凝作用并促进了纤维蛋白凝块的形成。血浆PAI-1抗原和活性水平与体重指数增加以及胰岛素抵抗综合征 (如肥胖和糖尿病) 的特征相关。内脏脂肪组织比皮下脂肪组织产生更多的PAI-1: 内脏脂肪组织产生的PAI-1增加是内脏肥胖和心血管疾病之间的重要联系。除了内脏脂肪组织外,越来越多的证据表明心外膜脂肪组织可能是PAI-1的重要来源,尤其是在2型糖尿病患者中。

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