Prostate-specific antigen (PSA), a glycoprotein initially thought to be produced only by the epithelial cells of the prostate, has recently been found in 30% of female breast tumours using immunofluorometry. Our aim was to localize PSA immunohistochemically in a selected group of 27 paraffin-embedded breast tissues. A scoring system was developed for the histological assessment of PSA positivity within the breast tissue. One pathologist (DH) scored, classified and graded all tumours. Site-specific PSA staining was noted in the histology slides. Intense staining was identified in apocrine metaplasia and within the lining ductal epithelium of cystically dilated ducts. The epithelium in lesions of sclerosing adenosis was also frequently positive for PSA staining. Hyperplastic ductal epithelium (especially of mild degree) occasionally stained positive, as did normal breast ducts. Better differentiated tumours showed PSA staining [e.g. mucinous carcinoma (colloid)]. If an infiltrating duct carcinoma showed staining for PSA, adjacent intraductal carcinoma was also noted to stain positively, if present.

译文

前列腺特异性抗原 (PSA) 是一种最初认为仅由前列腺的上皮细胞产生的糖蛋白,最近已在使用免疫荧光法的女性乳腺肿瘤30% 中发现。我们的目标是通过免疫组织化学方法将PSA定位在27个石蜡包埋的乳腺组织的选定组中。开发了一种评分系统,用于对乳腺组织内的PSA阳性进行组织学评估。一位病理学家 (DH) 对所有肿瘤进行评分,分类和分级。在组织学载玻片中发现了位点特异性PSA染色。在顶汗腺化生和膀胱扩张的导管上皮内发现了强烈的染色。硬化性腺病病变中的上皮也经常出现PSA染色阳性。增生的导管上皮 (尤其是轻度) 偶尔呈阳性,正常的乳腺导管也是如此。分化更好的肿瘤显示PSA染色 [例如粘液癌 (胶体)]。如果浸润性导管癌显示PSA染色,则邻近的导管内癌 (如果存在) 也被阳性染色。

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