We studied the in vitro effect of prolactin on the synthesis of prostaglandins PGE and PGF2 alpha in the rat uterus. Uterine tissue was obtained from ovariectomized adult rats with or without estradiol-17 beta treatment. Prolactin (4 IU/ml) enhanced PGE uterine synthesis. At higher concentrations (10-15 IU/ml) prolactin enhanced PGE levels and diminished PGE2 alpha production by uterine tissue from ovariectomized rats. When ovariectomized rats were injected with estradiol-17 beta, we observed a pattern of PGE and PGF2 beta uterine similar to that of ovariectomized rats. However, the stimulatory action of PRL on PGE synthesis was augmented in the estrogenized animals. These results led us to conclude that1)-PRL exerts a luteotrophic action by regulating uterine tissue PGE synthesis, 2-estradiol-17 beta potentiates this action.

译文

我们研究了催乳素对大鼠子宫中前列腺素PGE和pgf2α 合成的体外作用。从接受或不接受estradiol-17 β 处理的去卵巢成年大鼠获得子宫组织。催乳素 (4 IU/ml) 增强PGE子宫合成。在较高浓度 (10-15 IU/ml) 下,催乳素可增强去卵巢大鼠的子宫组织的PGE水平并减少pge2α 的产生。当卵巢切除的大鼠注射estradiol-17 β 时,我们观察到PGE和pgf2β 子宫模式与卵巢切除的大鼠相似。然而,在雌激素化动物中,PRL对PGE合成的刺激作用增强了。这些结果使我们得出结论,1)-PRL通过调节子宫组织PGE的合成来发挥黄体营养作用,2-estradiol-17β 增强了这种作用。

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