Paraquat is known to cause severe lung damage through pulmonary edema as its initial feature of toxicity. The purpose of this study was to investigate the toxicity of paraquat in rabbits intraperitoneally injected with 2 or 4 mg/kg/day of the herbicide for a period of 7 days. In the lung, prostaglandin levels of the intoxicated rabbits showed a significant increase in PGF2 alpha. This increase was dose dependent. However, a nonsignificant change in the 6-keto-PGF1 alpha was also observed. Plasma and serum levels of thromboxane-B2 were also significantly elevated but the levels of 6-keto-PGF1 alpha were affected nonsignificantly. The pathology of elevated levels of PGF2 alpha and TXB2 in the lung and blood, in response to paraquat toxicity, is discussed.

译文

百草枯已知通过肺水肿引起严重的肺损伤,这是其毒性的最初特征。目的研究百草枯对家兔腹腔注射2或4 mg/kg/天的除草剂,为期7天的毒性。在肺中,中毒兔子的前列腺素水平显示pgf2α 显着增加。这种增加是剂量依赖性的。然而,也观察到6-keto-pgf1α 无显著变化。thromboxane-B2的血浆和血清水平也显着升高,但6-keto-pgf1α 的水平没有显着影响。讨论了响应百草枯毒性的肺和血液中pgf2α 和TXB2水平升高的病理。

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