Schistosomiasis control programs aim to reduce morbidity but are evaluated by infection prevalence and intensity reduction. We present baseline cross-sectional data from a nested cohort study comparing indicators of morbidity for measuring program impact. Eight hundred twenty-two schoolchildren 7-8 years of age from Nyanza Province, Kenya, contributed stool for diagnosis of Schistosoma mansoni and soil-transmitted helminths (STH) and blood smears for malaria, and were evaluated for anemia, quality of life, exercise tolerance, anthropometry, and ultrasound abnormalities. Schistosoma mansoni, STH, and malaria infection prevalence were 69%, 25%, and 8%, respectively. Only anemia and S. mansoni infection (adjusted odds ratio [aOR] = 1.70; confidence interval [CI] = 1.03-2.80), and hepatomegaly and heavy S. mansoni infection (aOR = 2.21; CI = 1.19-4.11) were associated. Though anemia and hepatomegaly appeared most useful at baseline, additional morbidity indicators may be sensitive longitudinal measures to evaluate schistosomiasis program health impact.

译文

血吸虫病控制计划旨在降低发病率,但通过感染率和强度降低来评估。我们提供了一项嵌套队列研究的基线横断面数据,比较了发病率指标以衡量计划的影响。来自肯尼亚Nyanza省的82名7-8岁的学童为诊断曼氏血吸虫和土壤传播的蠕虫 (STH) 和血液涂片提供了粪便,并评估了贫血,生活质量,运动耐受性,人体测量学和超声异常。曼氏血吸虫,STH和疟疾感染率分别为69%,25% 和8%。仅贫血和曼氏沙氏菌感染 (调整后的比值比 [aOR] = 1.70; 置信区间 [CI] = 1.03-2.80),以及肝肿大和重度曼氏沙氏菌感染 (aOR = 2.21; CI = 1.19-4.11) 相关。尽管贫血和肝肿大在基线时似乎最有用,但其他发病率指标可能是评估血吸虫病计划对健康影响的敏感纵向指标。

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