Leptin is a hormone secreted by adipocytes. Besides controlling appetite and body weight, it has been suggested that leptin plays a role in inflammation and hemopoiesis. In this study we demonstrate that the pro-inflammatory/hemopoietic cytokines, IL-1beta, IL-6, TNF-alpha, and interferon-gamma, significantly inhibit gene expression and secretion of leptin by bone marrow adipocytes. These findings are in agreement with the data recently obtained from non-medullary adipose tissues. Within the bone marrow environment, leptin regulation by these pleiotropic cytokines could contribute to controlling the proliferation and differentiation of hemopoietic precursors as well as the maturation of stromal cells.

译文

瘦素是一种由脂肪细胞分泌的激素。除了控制食欲和体重外,还表明瘦素在炎症和造血中起作用。在这项研究中,我们证明了促炎/造血细胞因子IL-1beta,IL-6,TNF-α 和干扰素-γ 显着抑制骨髓脂肪细胞的基因表达和瘦素分泌。这些发现与最近从非髓脂肪组织获得的数据一致。在骨髓环境中,这些多效性细胞因子对瘦素的调节可能有助于控制造血前体的增殖和分化以及基质细胞的成熟。

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