Several ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and Rg3) are neuroprotective and antinociceptive agents. In this study, we assessed the effects of these ginsenosides following intracerebroventricular (i.c.v.) administration on the nociceptive behaviors induced by intrathecal injection of pro-inflammatory cytokines (tumor necrosis factor-a (TNF-alpha), interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma)). The ginsenosides, Rb1, Rb2, Rc, Rd, Re, Rf and Rg1, significantly attenuated the nociceptive behavior induced by TNF-alpha, IL-1 beta, and IFN-gamma injection, but ginsenoside-Rg3 did not. These results suggest that several ginsenosides may regulate the nociceptive processing induced by pro-inflammatory cytokines.

译文

几种人参皂甙 (Rb1、Rb2、Rc、Rd、Re、Rf、Rg1和Rg3) 是神经保护和抗伤害感受性药。在这项研究中,我们评估了这些人参皂甙在脑室内 (i.c.v.) 给药后对鞘内注射促炎性细胞因子 (肿瘤坏死因子-a (TNF-α),interleukin-1 β (IL-1 β),和干扰素-γ (IFN-γ)。人参皂苷Rb1,Rb2,Rc,Rd,Re,Rf和Rg1显着减弱了TNF-α,IL-1 β 和IFN-γ 注射引起的伤害性行为,但ginsenoside-Rg3没有。这些结果表明,几种人参皂甙可能调节促炎细胞因子诱导的伤害性过程。

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