Oral cancer is a neoplasm with some known causes. Proliferation genes are significant among its few pathogenetic and prognostic factors. Calcyclin is a cell-cycle-related gene, the function of which is still unclear. Its expression and that of Haras and histone-H3 have been investigated in an assessment of their pathogenetic role in squamous cell carcinoma. RNA extracted from the pathological and normal mucosa of patients with squamous cell carcinoma (SCC) and benign lesions was reverse transcribed and amplified by the polymerase chain reaction (PCR). The expression of all three genes in the pathological mucosa was enhanced in SCC only. This suggests that they may be involved in its pathogenesis and provides another parameter for the differentiation of malignant and benign lesions.

译文

口腔癌是一种已知病因的肿瘤。增殖基因在其少数致病和预后因素中具有重要意义。钙周期蛋白是一个与细胞周期相关的基因,其功能尚不清楚。在评估其在鳞状细胞癌中的致病作用时,已研究了其表达以及Haras和histone-H3的表达。从鳞状细胞癌 (SCC) 和良性病变患者的病理和正常粘膜中提取的RNA被逆转录并通过聚合酶链反应 (PCR) 扩增。仅在SCC中,病理粘膜中所有三个基因的表达均增强。这表明它们可能参与其发病机理,并为恶性和良性病变的鉴别提供了另一个参数。

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