A novel withanolide glucoside, plantagiolide I (1), a new withanolide glucoside, plantagiolide J (2), and six known compounds (3-8) were isolated from the whole plant of Tacca plantaginea. Their structures were determined by spectroscopic and chemical methods. Compound 3 significantly inhibited tumor necrosis factor alpha (TNFα)-induced nuclear factor-kappaB (NF-κB) transcriptional activity in HepG2 cells in a dose-dependent manner, with IC(50) values of 9.0 µM. Compounds 1-8 enhanced the transcriptional activity of peroxisome proliferator-activated receptors (PPARs) in a dose-dependent manner, with EC(50) values ranging from 1.6 to 49.7 µM. In addition, the transactivational effects of compounds 1-8 on three individual PPAR subtypes, including PPARα, β(δ), and γ were evaluated. Compounds 1-8 significantly activated the transcriptional activity of PPARβ(δ), with EC(50) values in a ranging from 4.1 to 29.6 µM. These results provide scientific support for the use of T. plantaginea and its components for the prevention and treatment of inflammatory and metabolic diseases.

译文

从Tacca plantaginea的整个植物中分离出一种新的withanolide葡萄糖苷,plantagiolide I (1),一种新的withanolide葡萄糖苷,plantagiolide J (2) 和六种已知化合物 (3-8)。它们的结构通过光谱和化学方法确定。化合物3以剂量依赖性方式显著抑制肿瘤坏死因子 α (tnf α) 诱导的HepG2细胞核因子 κ b (NF-κ b) 转录活性,IC(50) 值为9.0 µm µ m。化合物1-8以剂量依赖性方式增强过氧化物酶体增殖物激活受体 (ppar) 的转录活性,EC(50) 值范围为1.6至49.7 µm µ m。此外,还评估了化合物1-8对三种单独的PPAR亚型 (包括PPAR α,β(δ) 和 γ) 的反式激活作用。化合物1-8显著激活ppar β(δ) 的转录活性,EC(50) 值范围为4.1至29.6  µ m。这些结果为使用车前草及其成分预防和治疗炎症和代谢性疾病提供了科学支持。

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