In our screening program for antihypertensive plant constituents extracts of the leaves and bark of Badula barthesia showed strong in vitro inhibition of angiotensin converting enzyme (ACE). Rapanone (1), 2,5-dihydroxy-3-tridecyl-1,4-benzoquinone, was isolated as an active constituent of the leaves. The IC(50) values of rapanone and three 3-alkyl-2,5-dihydroxybenzoquinones, (2)-(4), (Z)-2,5-dihydroxy-3-(pentadec-8-enyl)-1,4-benzoquinone, (Z,Z)-2,5-dihydroxy-3-(heptadeca-8,11-dienyl)-1,4-benzoqui-none and (Z)-2,5-dihydroxy-3-(heptadec-8-enyl)-1,4-benzoquinone recently isolated from Embelia angustifolia were determined. The following IC(50) ± S.D. values have been obtained (1) 36 ± 4.6 μM, (2) 19 ± 6.2 μM, (3) 19 ± 8.7 μM and (4) 16 ± 3.0 μ.M. The IC(50) value for the reference compound Captopril was determined to 12 ± 2.6 nM. The antimicrobial activity of the four compounds was determined by thin layer chromatography agar overlay technique as minimum growth inhibitory amount in μg. One yeast, Candida albicans, and four bacteria, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were used as test organisms.

译文

在我们的抗高血压植物成分筛选程序中,巴杜拉 (Badula) 的叶片和树皮的提取物显示出对血管紧张素转化酶 (ACE) 的强烈体外抑制作用。分离出雷帕酮 (1),2,5-二羟基-3-三癸基-1,4-苯醌作为叶片的活性成分。雷帕酮和三种3-烷基-2,5-二羟基苯醌,(2)-(4),(Z)-2,5-二羟基-3-(pentadec-8-enyl)-1,4-苯醌,(Z,Z)-2,5-二羟基-3-(heptadeca-8,11-二烯基)-1,测定了最近从angustifolia中分离出的4-苯醌-none和 (Z)-2,5-二羟基-3-(heptadec-8-enyl)-1,4-苯醌。已获得以下IC(50) ± S.D. 值 (1) 36 ± 4.6微米,(2) 19 ± 6.2微米,(3) 19 ± 8.7微米和 (4) 16 ± 3.0微米。参考化合物卡托普利的IC(50) 值确定为12 ± 2.6 nM。通过薄层色谱琼脂覆盖技术确定四种化合物的抗菌活性为最小生长抑制量 (μ g)。以1个酵母菌、白色念珠菌和4个细菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌为试验生物。

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