The purpose of the present study was to establish a rat bipedal walking model to examine the effects of bipedal walking on the central nervous system by training rats to perform bipedal walking over a period of 3 months. The characteristics of bipedal walking were investigated using kinematic and electromyographic methods in established bipedal walking models. Stable bipedal walking was achieved in rats by training them to stand with an upright posture and to walk with the hindlimbs using bipedal-walking training equipment to obtain a water reward. A stable head position in the rat bipedal walking model was attained primarily by closing the swing-phase period with a large angular change in the hip, knee, and ankle joints. The EMG burst pattern of the knee extensor (m. rectus femoris) and the erector muscle of the spine (m. longissimus) during bipedal walking was similar to that during quadrupedal walking in rats. We established two bipedal walking models using normal and forelimb-amputated rats. Comparative studies of these two bipedal walking models are expected to provide the information about the influence of forelimb movements on neuronal control of bipedal walking.

译文

本研究的目的是建立大鼠双足步行模型,通过训练大鼠进行3个月的双足步行来检查双足步行对中枢神经系统的影响。在建立的双足步行模型中,使用运动学和肌电图方法研究了双足步行的特征。通过训练大鼠以直立姿势站立并使用双足行走训练设备与后肢行走以获得水奖励,可以在大鼠中实现稳定的双足行走。大鼠双足步行模型中的稳定头部位置主要是通过在髋关节,膝关节和踝关节的角度变化较大的情况下结束摆动阶段来实现的。两足行走过程中膝盖伸肌 (股直肌) 和脊柱直立肌 (长肌) 的EMG爆发模式与大鼠四足行走过程中相似。我们使用正常和前肢截肢的大鼠建立了两个双足步行模型。对这两种双足步行模型的比较研究有望提供有关前肢运动对双足步行神经元控制的影响的信息。

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