MicroRNA-203 (miR-203), possessing tumor suppressive or promotive activities, has been found to be downregulated or upregulated in different cancer types. The purpose of this study was to investigate whether the increased expression of miR-203 can be used as a noninvasive diagnostic and prognostic biomarker in epithelial ovarian cancer (EOC). Real-time quantitative PCR was performed to detect the expression levels of miR-203 in EOC tissues. The expression levels of miR-203 were significantly higher in EOC tissues compared to adjacent non-cancerous tissues (p < 0.001). High expression of miR-203 was observed in 65.38 % (102/156) of EOC. In addition, high miR-203 expression was found to be closely correlated with advanced FIGO stage (p < 0.001), higher histological grade (p = 0.02), lymph node involvement (p < 0.001), and positive recurrence (p < 0.001). Moreover, high miR-203 expression was correlated with shorter overall survival (p < 0.001) and shorter progression-free survival (p < 0.001) of EOC patients. Furthermore, multivariate analysis showed that the status of miR-203 expression was an independent predictor for both overall survival and progression-free survival in EOC. These findings provide the convincing evidence for the first time that the upregulation of miR-203 may serve as a novel molecular marker to predict the aggressive tumor progression and unfavorable prognosis of EOC patients.

译文

MicroRNA-203 (miR-203) 具有肿瘤抑制或促进活性,已发现在不同类型的癌症中被下调或上调。这项研究的目的是研究miR-203表达的增加是否可以用作上皮性卵巢癌 (EOC) 的非侵入性诊断和预后生物标志物。进行实时定量PCR以检测EOC组织中miR-203的表达水平。与邻近的非癌组织相比,EOC组织中miR-203的表达水平显着更高 (p <0.001)。在65.38% (102/156) 的EOC中观察到miR-203的高表达。此外,发现高miR-203表达与FIGO分期 (p <0.001),组织学分级 (p = 0.02),淋巴结受累 (p < 0.001) 和阳性复发 (p < 0.001) 密切相关。此外,高miR-203表达与EOC患者更短的总生存期 (p < 0.001) 和更短的无进展生存期 (p < 0.001) 相关。此外,多变量分析表明,miR-203表达状态是EOC总生存期和无进展生存期的独立预测因子。这些发现首次提供了令人信服的证据,表明miR-203的上调可能是预测EOC患者侵袭性肿瘤进展和不良预后的新型分子标记。

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