Recent genome searches suggest a putative linkage of many loci to susceptibility to type I diabetes. The chromosome 2q31-35 region is reported to be linked to susceptibility to type I diabetes and is thought to contain several diabetes susceptibility loci. These candidate genes include the HOXD gene cluster, BETA2, CTLA4, CD28, IGFBP2, and IGFBP5. Association studies in populations and families are required to confirm and/or identify the actual susceptibility loci. We hereby report several previously unknown DNA polymorphisms for HOXD8, BETA2, and IGFBP5, which we have used along with previously known polymorphisms of HOXD8 and CTLA4 to test whether these candidate loci are the susceptibility genes on chromosome 2q31-35. Using a case-control design with a subsequent family-association approach to confirm associations, we find no evidence that these candidate genes are associated with susceptibility to type I diabetes.

译文

最近的基因组搜索表明,许多基因座与I型糖尿病易感性之间存在推定的联系。据报道,染色体2q31-35区域与I型糖尿病的易感性有关,并被认为包含多个糖尿病易感性位点。这些候选基因包括HOXD基因簇,BETA2,CTLA4,CD28,IGFBP2和igfbp5。需要在人群和家庭中进行关联研究,以确认和/或确定实际的易感性位点。我们在此报告了HOXD8,BETA2和IGFBP5的几个先前未知的DNA多态性,我们将其与先前已知的HOXD8和CTLA4的多态性一起使用,以测试这些候选基因座是否是染色体2q31-35上的易感基因。使用病例对照设计和随后的家庭关联方法来确认关联,我们没有发现证据表明这些候选基因与I型糖尿病的易感性有关。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录