Background: The measurement of impedance permits reliable detection of obstructive apneas, hypopneas and upper airways resistance syndrome.Objective: To establish whether impedance-controlled self-adjusting positive airway pressure therapy (APAP(FOT)) is equally as good as constant continuous positive airway pressure (CPAP) in the treatment of sleep apnea syndrome (OSAS).Methods: Twenty men and five women with OSAS (age 52.8+/-9.0 years, body mass index (BMI) 31.4+/-5.0 kg/m(2), AHI 32.2+/-18.1/h (mean+/-SD)) underwent baseline polysomnography, manual CPAP titration and two nights of treatment, one with APAP(FOT), one with constant CPAP.Results: With both modes, a significant reduction in respiratory disturbances was seen (apnea/hypopnea index (AHI) baseline 32.2+/-18.1/h, constant CPAP 6.6+/-8.7, APAP(FOT) 5.5+/-3.8/h, P<0.001 baseline vs. each treatment mode). Under APAP(FOT), the sleep profile was normalized (S3/4 baseline 16.3+/-13.9% total sleep time (TST), APAP(FOT) 21.6+/-10.9% TST, P<0.05, rapid eye movement (REM) 14.2+/-6.7% TST vs. 20.3+/-7.3% TST, P<0.01), while with constant CPAP, a tendency towards improvement was found. The mean treatment pressure with APAP(FOT) was significantly lower than the constant CPAP (5.7+/-2.1 vs. 8.3+/-1.6 mbar, P<0.001).Conclusion: We conclude that APAP(FOT) is at least as effective as constant CPAP in normalizing sleep and breathing in OSAS.

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背景: 阻抗的测量可以可靠地检测阻塞性呼吸暂停,呼吸不足和上呼吸道阻力综合征。目的: 确定阻抗控制的自调节气道正压疗法 (APAP(FOT)) 在治疗睡眠呼吸暂停综合征 (OSAS) 中是否与持续气道正压疗法 (CPAP) 一样好。方法: 20名男性和5名女性oas (年龄52.8 +/-9.0岁,体重指数 (BMI) 31.4 +/-5.0千克/m(2),AHI 32.2 +/-18.1/h (平均 +/-SD)) 接受基线多导睡眠监测,手动CPAP滴定和两晚治疗,一次使用APAP(FOT),一次使用恒定CPAP。结果: 在两种模式下,呼吸障碍均显着降低 (呼吸暂停/低通气指数 (AHI) 基线32.2/-18.1/h,恒定CPAP 6.6/-8.7,APAP(FOT) 5.5 +/-3.8/h,P<0.001基线vs.每种治疗模式)。在APAP(FOT) 下,睡眠曲线被标准化 (S3/4基线16.3 +/-13.9% 总睡眠时间 (TST),APAP(FOT) 21.6 +/-10.9% TST,P<0.05,快速眼动 (REM) 14.2 +/-6.7% TST与20.3 +/-7.3% TST,P<0.01),而在持续CPAP的情况下,发现有改善的趋势。APAP的平均治疗压力 (FOT) 明显低于恒定CPAP (5.7 +/-2.1 vs. 8.3 +/-1.6 mbar,P<0.001)。结论: 我们得出的结论是,APAP(FOT) 在oas的睡眠和呼吸正常化方面至少与恒定CPAP一样有效。

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