A novel and functional conjugative transfer system identified in O119:H2 enteropathogenic Escherichia coli (EPEC) strain MB80 by subtractive hybridization is encoded on a large multidrug resistance plasmid, distinct from the well-described EPEC adherence factor (EAF) plasmid. Variants of the MB80 conjugative resistance plasmid were identified in other EPEC strains, including the prototypical O111:NM strain B171, from which the EAF plasmid has been sequenced. This separate large plasmid and the selective advantage that it confers in the antibiotic era have been overlooked because it comigrates with the virulence plasmid on conventional gels.

译文

通过消减杂交在O119:H2肠致病性大肠杆菌 (EPEC) 菌株MB80中鉴定出的新颖且功能强大的共轭转移系统被编码在大型多药耐药质粒上,与描述明确的EPEC粘附因子 (EAF) 质粒不同。在其他EPEC菌株中鉴定了MB80共轭抗性质粒的变体,包括原型O111:NM菌株B171,从中对EAF质粒进行了测序。这种单独的大质粒及其在抗生素时代赋予的选择性优势被忽略了,因为它与常规凝胶上的毒力质粒共同存在。

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