Pregnancy encompasses substantial changes in vascular function to accommodate dramatic increases in blood volume and uteroplacental blood flow to the growing fetus. Despite increased hemodynamics, decreased peripheral resistance results in a reduction in mean arterial blood pressure. Vascular tone, and hence peripheral resistance, is determined by a delicate balance of constrictor and dilator capacities. In the normal physiological response to pregnancy, endothelial-derived hyperpolarization (EDH) has been shown to be a major contributor; both EDH and nitric oxide (NO) are predominantly involved in providing an increased vascular capacity for vasodilation. The ability of EDH and NO to adequately accommodate increased blood volume is tested in pathological states such as placental insufficiency or diabetes and both EDH and NO-dependent mechanisms seem to be impacted in these situations. Pregnancy complications also have an impact on the cardiovascular health of the offspring. In adult offspring born from complicated pregnancies, the data suggest that EDH mechanisms are largely maintained, whereas NO is commonly reduced. A diversity of EDH mechanisms may be useful in providing many targets for potential therapeutic avenues for compromised pregnancies; however, further research delineating the mechanisms of EDH and the interactions of NO and EDH, in normal and pathological pregnancies is required.

译文

怀孕包括血管功能的重大变化,以适应血容量和子宫胎盘血流量的急剧增加。尽管血流动力学增加,但外周阻力降低会导致平均动脉血压降低。血管张力以及外周阻力是由收缩器和扩张器能力的微妙平衡决定的。在对妊娠的正常生理反应中,内皮衍生的超极化 (EDH) 已被证明是主要的贡献者; EDH和一氧化氮 (NO) 都主要参与增加血管舒张能力。在病理状态 (例如胎盘功能不全或糖尿病) 中测试了EDH和NO充分适应增加的血容量的能力,在这些情况下,EDH和NO依赖性机制似乎都受到影响。妊娠并发症也会对后代的心血管健康产生影响。在复杂怀孕出生的成年后代中,数据表明EDH机制在很大程度上得以维持,而NO通常会减少。EDH机制的多样性可能有助于为受损妊娠的潜在治疗途径提供许多靶标; 但是,需要进一步研究描述正常和病理性妊娠中EDH的机制以及NO和EDH的相互作用。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录