The objective of this study was to determine if very early ultrasonographic measurements obtained from human and baboon are comparable. For this purpose, the gestational, amniotic and yolk sacs, embryonic crown rump length (CRL) and heart rate were measured ultrasonographically between 35 and 47 days from the mean day of a three-day mating period in baboons (n=18) and between 42 to 58 days from fertilization as calculated from the CRL measurements in human pregnancies (n=82). Ultrasonographic measurements from both species were then plotted in the same graph using Carnegie stages of embryonic development as the independent variable to allow for visual comparisons. Mean gestational age at ultrasonographic studies was significantly different for humans and baboons (50.4 vs. 41 days, respectively; p>0.01). Significant correlations (p>0.01) were noted between ultrasonographic measurements and Carnegie stages of development in both humans and baboons. Only the gestational and the yolk sacs were significantly smaller in baboons than in humans (p>0.05). The findings that embryonic CRL, extra-embryonic space and heart rate are very similar between the 17th and 23rd Carnegie developmental stages make the baboon a promising surrogate of human pregnancy for investigations using celocentesis.

译文

这项研究的目的是确定从人类和狒狒获得的非常早期的超声检查结果是否具有可比性。为此,妊娠、羊膜和卵黄囊,从狒狒的三天交配期的平均一天 (n = 18) 和受精后的42至58天之间,超声测量了胚胎冠的臀部长度 (CRL) 和心率 (n = 82)。然后使用卡内基胚胎发育阶段作为自变量,将两个物种的超声测量结果绘制在同一图中,以进行视觉比较。在超声检查研究中,人类和狒狒的平均胎龄显着不同 (分别为50.4天与41天; p>0.01)。在人类和狒狒的超声测量与卡内基发育阶段之间发现了显着的相关性 (p>0.01)。狒狒中只有妊娠和卵黄囊明显小于人类 (p>0.05)。在第17和第23卡内基发育阶段之间,胚胎CRL,胚胎外空间和心率非常相似的发现使狒狒成为人类怀孕的有前途的替代品,可用于使用celecentesis进行研究。

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