Purpose. To evaluate whether 3T clinical MRI with a small-animal coil and gradient-echo (GE) sequence could be used to characterize long-term left ventricular remodelling (LVR) following nonreperfused myocardial infarction (MI) using semi-automatic segmentation software (SASS) in a rat model. Materials and Methods. 5 healthy rats were used to validate left ventricular mass (LVM) measured by MRI with postmortem values. 5 sham and 7 infarcted rats were scanned at 2 and 4 weeks after surgery to allow for functional and structural analysis of the heart. Measurements included ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and LVM. Changes in different regions of the heart were quantified using wall thickness analyses. Results. LVM validation in healthy rats demonstrated high correlation between MR and postmortem values. Functional assessment at 4 weeks after MI revealed considerable reduction in EF, increases in ESV, EDV, and LVM, and contractile dysfunction in infarcted and noninfarcted regions. Conclusion. Clinical 3T MRI with a small animal coil and GE sequence generated images in a rat heart with adequate signal-to-noise ratio (SNR) for successful semiautomatic segmentation to accurately and rapidly evaluate long-term LVR after MI.

译文

目的。评估是否可以使用半自动分割软件 (SASS) 在大鼠模型中使用带有小动物线圈和梯度回波 (GE) 序列的3t临床MRI来表征非再灌注心肌梗死 (MI) 后的长期左心室重塑 (LVR)。材料和方法。5只健康大鼠用于验证MRI测量的左心室质量 (LVM) 和死后值。在手术后2周和4周对5只假手术大鼠和7只梗死大鼠进行扫描,以进行心脏的功能和结构分析。测量包括射血分数 (EF),舒张末期容积 (EDV),收缩末期容积 (ESV) 和LVM。使用壁厚分析来量化心脏不同区域的变化。结果。健康大鼠的LVM验证表明MR与死后值之间存在高度相关性。MI后4周的功能评估显示EF显着降低,ESV,EDV和LVM增加以及梗塞和非梗塞区域的收缩功能障碍。结论。具有小动物线圈和GE序列的临床3T MRI在大鼠心脏中生成的图像具有足够的信噪比 (SNR),可成功进行半自动分割,以准确,快速地评估MI后的长期LVR。

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