Anaphylaxis is a life-threatening hypersensitivity reaction. To identify biomarkers for the condition, we assessed serum levels of apolipoprotein (Apo)A and ApoE. We found a reduction of both lipoproteins in anaphylactic mice as well as in orally challenged food allergic patients. We then compared patients after acute anaphylaxis with several control groups (nonallergic, history of allergen-triggered anaphylaxis, acute cardiovascular/febrile reactions). In this unpaired setting, ApoE levels were unaltered, while ApoA1 was reduced in the anaphylactic group. Although unable to discriminate between anaphylaxis and cardiovascular/febrile reactions, ROC curve analysis revealed a reasonably high area under the curve (AUC) of 0.91 for ApoA1. Serum 9α,11ß-PGF2 , recently identified as a suitable biomarker for anaphylaxis, outperformed ApoA1 with AUC=0.95. Intriguingly however its power further increased upon combination of both mediators reaching AUC=1. Our data suggest that ApoA1 combined with 9α,11ß-PGF2 represents a useful composite biomarker of anaphylaxis, achieving superior diagnostic power over either factor alone.

译文

过敏反应是一种危及生命的超敏反应。为了确定该疾病的生物标志物,我们评估了载脂蛋白 (Apo)A和ApoE的血清水平。我们发现过敏性小鼠和口服食物过敏患者的脂蛋白均减少。然后,我们将急性过敏反应后的患者与几个对照组 (非过敏性,过敏原引发过敏反应、急性心血管/发热反应的病史)。在这种未配对的情况下,ApoE水平没有改变,而过敏组ApoA1降低。尽管无法区分过敏反应和心血管/发热反应,ROC曲线分析显示apoa1的0.91曲线下面积 (AUC) 相当高。血清9α,11ß-pgf2,最近被确定为过敏反应的合适生物标志物,AUC = 0.95优于ApoA1。然而有趣的是,当两种介体结合达到AUC = 1时,其能力进一步增强。我们的数据表明,ApoA1与9α,11ß-pgf2结合代表了一种有用的过敏反应复合生物标志物,比单独任一因素都具有优异的诊断能力。

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