The endocannabinoid system (ECS) is a construct based on the discovery of receptors that are modulated by the plant compound tetrahydrocannabinol and the subsequent identification of a family of nascent ligands, the 'endocannabinoids'. The function of the ECS is thus defined by modulation of these receptors-in particular, by two of the best-described ligands (2-arachidonyl glycerol and anandamide), and by their metabolic pathways. Endocannabinoids are released by cell stress, and promote both cell survival and death according to concentration. The ECS appears to shift the immune system towards a type 2 response, while maintaining a positive energy balance and reducing anxiety. It may therefore be important in resolution of injury and inflammation. Data suggest that the ECS could potentially modulate mitochondrial function by several different pathways; this may help explain its actions in the central nervous system. Dose-related control of mitochondrial function could therefore provide an insight into its role in health and disease, and why it might have its own pathology, and possibly, new therapeutic directions.

译文

内源性大麻素系统 (ECS) 是基于发现受植物化合物四氢大麻酚调节的受体以及随后鉴定的新生配体家族 “内源性大麻素” 的构建体。因此,ECS的功能是通过调节这些受体来定义的,特别是通过两个最佳描述的配体 (2-花生四烯基甘油和anandamide) 以及它们的代谢途径。内源性大麻素通过细胞应激释放,并根据浓度促进细胞存活和死亡。ECS似乎将免疫系统转移到2型反应,同时保持正能量平衡并减少焦虑。因此,它可能对缓解损伤和炎症很重要。数据表明,ECS可能通过几种不同的途径调节线粒体功能; 这可能有助于解释其在中枢神经系统中的作用。因此,与剂量相关的线粒体功能控制可以深入了解其在健康和疾病中的作用,以及为什么它可能具有自己的病理学以及可能的新治疗方向。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录