This study used resting-state functional magnetic resonance imaging (fMRI) to investigate whether functional connectivity is altered in people developing post-traumatic stress disorder (PTSD) following recent trauma. Sixty-two participants who had experienced recent acute traumatic events underwent a 7.3 min resting fMRI scan within 2 days post accident. Of these, 22 participants were diagnosed with PTSD within 1 to 6 months. Nineteen age- and sex-matched subjects without PTSD were selected as the trauma-exposed control group. Posterior cingulate cortex connectivity was determined from 17 PTSD patients and 15 control subjects by investigating synchronic low-frequency fMRI signal fluctuations using a temporal correlation method. To assess the relationship between PTSD symptom severity and PCC connectivity, the contrast image representing areas correlated with the PCC was correlated with the 17 PTSD subjects' Clinician Administered PTSD Scale (CAPS) scores at diagnosis. Compared with the control group, PTSD patients exhibited decreased functional connectivity in the right lingual and right middle temporal gyri, and left lingual/posterior cingulate cortex. The left inferior temporal gyrus, right middle temporal gyrus, left middle temporal gyrus/insula, left medial frontal lobe/anterior cingulate cortex, and right medial frontal gyrus also showed increased connectivity within two days post accident. A negative correlation was found between PCC connectivity and CAPS scores in the left medial prefrontal cortex (mPFC). These results suggest that patients who develop PTSD exhibit different resting-state patterns of neuronal activity following recent trauma. Abnormal FC of mPFC may be a major risk factor predisposing patients to the development of PTSD.

译文

这项研究使用静息状态功能磁共振成像 (fMRI) 来调查最近发生创伤后发生创伤后应激障碍 (PTSD) 的人的功能连接是否发生改变。62名最近经历过急性创伤事件的参与者在事故发生后2天内接受了7.3分钟的静息fMRI扫描。其中,22名参与者在1至6个月内被诊断出患有PTSD。选择19名年龄和性别匹配的无PTSD受试者作为创伤暴露对照组。通过使用时间相关方法调查共时低频fMRI信号波动,确定了17名PTSD患者和15名对照受试者的后扣带回皮层连通性。为了评估PTSD症状严重程度与PCC连通性之间的关系,将代表与PCC相关区域的对比图像与17名PTSD受试者的临床医生在诊断时给予的PTSD量表 (CAPS) 评分相关。与对照组相比,PTSD患者的右舌和右中颞回以及左舌/后扣带回皮质的功能连接降低。事故发生后两天内,左侧颞下回,右侧颞下回,左侧颞下回/岛叶,左侧内侧额叶/前扣带回和右侧内侧额叶也显示连接增加。在左侧内侧前额叶皮层 (mPFC) 的PCC连通性与CAPS评分之间发现负相关。这些结果表明,发生PTSD的患者在最近的创伤后表现出不同的静息状态神经元活动模式。mPFC的FC异常可能是导致患者发生PTSD的主要危险因素。

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