Extranodal presentation in non-Hodgkin's lymphoma (NHL) is uncommon, and the mandible is very rarely involved. Primary NHL of the mandible, for the most part, has intermediate or high malignancy and has a much greater incidence of local recurrence compared with other sites of involvement. A 48-year-old Japanese man with NHL of the mandible received radiotherapy, followed by high-dose chemotherapy supported with peripheral blood stem cell transplantation (PBSCT). High-dose cyclophosphamide, Adriamycin, and vincristine were used for pretransplant conditioning. He achieved complete remission and has survived in continuous complete remission for more than 72 months to date. Marrow-ablative chemotherapy facilitated by PBSCT is thought to be useful as part of the primary therapy for patients with NHL who have poorer prognoses.

译文

非霍奇金淋巴瘤 (NHL) 的结外表现并不常见,下颌骨很少涉及。与其他受累部位相比,下颌骨的原发性NHL大部分具有中等或高度恶性,并且局部复发的发生率更高。一名48岁的日本下颌骨NHL男子接受了放疗,随后接受了大剂量化疗,并伴有外周血干细胞移植 (PBSCT)。大剂量环磷酰胺,阿霉素和长春新碱用于移植前调理。迄今为止,他获得了完全缓解,并且在连续完全缓解中存活了72个月以上。PBSCT促进的骨髓消融化疗被认为是对预后较差的NHL患者的主要治疗的一部分。

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