To investigate if the surface modification of intraocular lens (IOL) is efficient in the prevention of posterior capsular opacification (PCO), the acrylic surface of intraocular lens (Acrysof) was polymerized with polyethylene glycol (PEG-IOL). The human lens epithelial cells (1 x 10(4) cells/mL) were inoculated on PEG grafted or unmodified acrylic lenses for the control. The adherent cells on each IOL surface were trypsinized and counted. The every PEG-IOL was implanted in 20 New Zealand rabbits after removal of crystalline lens. The formations of PCO were checked serially through retroilluminated digital photography, and the severity scores were calculated using POCOman. The cell adherence patterns on each IOL were examined by scanning electron microscopy. As a result, the mean number of adherent cells of PEG-IOL (3.2+/-1.1 x 10(3)) tended to be smaller than that of the acrylic controls (3.6+/-1.9 x 10(3)) without a statistical significance (p=0.73). However, the mean severity of PCO formation in PEG-IOL was significantly lower than that in the control during the third to sixth weeks after surgery. Scanning electron microscopy revealed that the more patch-like cells were found firmly attached to the IOL surface in control than in the PEG-IOL. Conclusively, PEG polymerization to the acrylic IOL would possibly lessen the formation of PCO after cataract removal.

译文

为了研究人工晶状体 (IOL) 的表面改性是否能有效预防后囊混浊 (PCO),人工晶状体 (Acrysof) 的丙烯酸表面与聚乙二醇 (PEG-IOL) 聚合。将人晶状体上皮细胞 (1x10(4) 细胞/mL) 接种在PEG移植或未修饰的丙烯酸镜片上,以进行对照。对每个IOL表面的贴壁细胞进行胰蛋白酶处理并计数。去除晶状体后,将每只PEG-IOL植入20只新西兰兔子中。通过逆光数码摄影连续检查PCO的形成,并使用pocomanan计算严重程度评分。通过扫描电子显微镜检查每个IOL上的细胞粘附模式。结果,PEG-IOL的贴壁细胞的平均数目 (3.2 +/-1.1 × 10(3)) 趋向于小于丙烯酸对照的数目 (3.6 +/-1.9 × 10(3)),没有统计学意义 (p = 0.73)。然而,在术后第三至第六周,PEG-IOL中PCO形成的平均严重程度显着低于对照组。扫描电子显微镜显示,与PEG-IOL相比,对照中发现更多的斑块状细胞牢固地附着在IOL表面。最终,聚乙二醇聚合到丙烯酸IOL可能会减少白内障摘除后PCO的形成。

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